Mitochondrial Dysfunction
Deregulated Nutrient Sensing
Loss of Proteostasis
Epigenetic Alterations
Telomere Attrition
Genomic Instability
Altered intercellular communication
Stem cells Exhaustion
Cellular senescence
The 9 Hallmarks of Aging
There are many definitions of ageing. A popular way to discuss ageing is the 9 hallmarks of aging.
Sirtuins
The Longevity Sirtuins
The seven type of genes (SIRT 1, 2, 3, 4, 5, 6, 7) impact on how well we age
The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors such as NMN, have improved organ function, physical endurance, disease resistance and longevity.
Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans. [1]